Healthier kids, brighter futures

Research

Publications

Cancer Research Unit
 

Key Publications

  1. Telomere elongation in immortal human cells without detectable telomerase activity. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. EMBO J. 1995, 14: 4240-4248. PMID: 7556065.
  2. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA and Reddel RR. Nature Med. 1997, 3: 1271-1274. PMID: 9359704
  3. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Kilian A, Bowtell DDL, Abud HE, Hime GR, Venter DJ, Keese PK, Duncan EL, Reddel RR and Jefferson RA. Hum. Mol. Genet. 1997, 6: 2011-2019. PMID: 9328464
  4. Telomere maintenance by recombination in human cells. Dunham MA, Neumann AA, Fasching CL and Reddel RR. Nature Genet. 2000, 26: 447-450. PMID: 11101843
  5. Protein composition of catalytically active human telomerase from immortal cells. Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ and Reddel RR. Science 2007, 315: 1850-3. PMID: 17395830

Review Articles

  1. Telomere maintenance mechanisms in cancer: clinical implications. Reddel,R.R. Curr. Pharm. Des. 2014. PMID:24975603.
  2. Alternative lengthening of telomeres: remodeling the telomere architecture. Conomos,D., Pickett,H.A., and Reddel,R.R. Front. Oncol. 2013 3: 27. PMID: 23429284.
  3. Cancer and telomeres - an ALTernative to telomerase. Shay JW, Reddel RR, Wright WE. Science 2012 336:1388-90. PMID:22700908.
  4. Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers. Henson JD, Reddel RR. FEBS Lett. 2010, 584 (17): 3800-11. PMID: 20542034.
  5. Check your cultures! A list of cross-contaminated or misidentified cell lines. Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, Macleod RA, Masters JR, Nakamura Y, Reid YA, Reddel RR, Freshney RI.  Int. J Cancer 2010, 127 (1): 1-8. PMID: 20143388.
  6. Alternative lengthening of telomeres: models, methods and implications. Cesare AJ and Reddel RR. Nat. Rev. Genet. 2010, 11 (5): 319-30. PMID: 20351727
  7. Senescence: an antiviral defense that is tumor suppressive? Reddel RR. Carcinogenesis 2010, 31 (1): 19-26. PMID: 19887513.
     

Recent Publications

  1. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Conomos,D., Reddel, R.R., and Pickett,H.A. Nat. Struct. Mol. Biol. 2014 21:760-770. PMID: 25150861.
  2. Detection of alternative lengthening of telomeres by telomere quantitative PCR. Lau,L.M., Dadd,R.A., Henson,J.D., Au,A.Y., Royds,J.A., and Reddel,R.R. Nucleic Acids Res. 2013 41: e34. PMID: 22923525.
  3. Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Lee M, Hills M, Conomos D, Stutz MD, Dagg RA, Lau LM, Reddel RR, Pickett HA. Nucleic Acids Res. 2013 Nov 12. [Epub ahead of print] PMID: 24225324.
  4. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, Karevan R, Woods N, Johnston RL, French JD, Chen X, Weischer M, Nielsen SF, Maranian MJ, Ghoussaini M, Ahmed S, Baynes C, Bolla MK, Wang Q, Dennis J, McGuffog L, Barrowdale D, Lee A, Healey S, Lush M, Tessier DC, Vincent D, Bacot F; Australian Cancer Study; Australian Ovarian Cancer Study; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Gene Environment Interaction and Breast Cancer (GENICA); Swedish Breast Cancer Study (SWE-BRCA); Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE); Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), Vergote I, Lambrechts S, Despierre E, Risch HA, González-Neira A, Rossing MA, Pita G, Doherty JA, Alvarez N, Larson MC, Fridley BL, Schoof N, Chang-Claude J, Cicek MS, Peto J, Kalli KR, Broeks A, Armasu SM, Schmidt MK, Braaf LM, Winterhoff B, Nevanlinna H, Konecny GE, Lambrechts D, Rogmann L, Guénel P, Teoman A, Milne RL, Garcia JJ, Cox A, Shridhar V, Burwinkel B, Marme F, Hein R, Sawyer EJ, Haiman CA, Wang-Gohrke S, Andrulis IL, Moysich KB, Hopper JL, Odunsi K, Lindblom A, Giles GG, Brenner H, Simard J, Lurie G, Fasching PA, Carney ME, Radice P, Wilkens LR, Swerdlow A, Goodman MT, Brauch H, Garcia-Closas M, Hillemanns P, Winqvist R, Dürst M, Devilee P, Runnebaum I, Jakubowska A, Lubinski J, Mannermaa A, Butzow R, Bogdanova NV, Dörk T, Pelttari LM, Zheng W, Leminen A, Anton-Culver H, Bunker CH, Kristensen V, Ness RB, Muir K, Edwards R, Meindl A, Heitz F, Matsuo K, du Bois A, Wu AH, Harter P, Teo SH, Schwaab I, Shu XO, Blot W, Hosono S, Kang D, Nakanishi T, Hartman M, Yatabe Y, Hamann U, Karlan BY, Sangrajrang S, Kjaer SK, Gaborieau V, Jensen A, Eccles D, Høgdall E, Shen CY, Brown J, Woo YL, Shah M, Azmi MA, Luben R, Omar SZ, Czene K, Vierkant RA, Nordestgaard BG, Flyger H, Vachon C, Olson JE, Wang X, Levine DA, Rudolph A, Weber RP, Flesch-Janys D, Iversen E, Nickels S, Schildkraut JM, Silva Idos S, Cramer DW, Gibson L, Terry KL, Fletcher O, Vitonis AF, van der Schoot CE, Poole EM, Hogervorst FB, Tworoger SS, Liu J, Bandera EV, Li J, Olson SH, Humphreys K, Orlow I, Blomqvist C, Rodriguez-Rodriguez L, Aittomäki K, Salvesen HB, Muranen TA, Wik E, Brouwers B, Krakstad C, Wauters E, Halle MK, Wildiers H, Kiemeney LA, Mulot C, Aben KK, Laurent-Puig P, Altena AM, Truong T, Massuger LF, Benitez J, Pejovic T, Perez JI, Hoatlin M, Zamora MP, Cook LS, Balasubramanian SP, Kelemen LE, Schneeweiss A, Le ND, Sohn C, Brooks-Wilson A, Tomlinson I, Kerin MJ, Miller N, Cybulski C, Henderson BE, Menkiszak J, Schumacher F, Wentzensen N, Le Marchand L, Yang HP, Mulligan AM, Glendon G, Engelholm SA, Knight JA, Høgdall CK, Apicella C, Gore M, Tsimiklis H, Song H, Southey MC, Jager A, den Ouweland AM, Brown R, Martens JW, Flanagan JM, Kriege M, Paul J, Margolin S, Siddiqui N, Severi G, Whittemore AS, Baglietto L, McGuire V, Stegmaier C, Sieh W, Müller H, Arndt V, Labrèche F, Gao YT, Goldberg MS, Yang G, Dumont M, McLaughlin JR, Hartmann A, Ekici AB, Beckmann MW, Phelan CM, Lux MP, Permuth-Wey J, Peissel B, Sellers TA, Ficarazzi F, Barile M, Ziogas A, Ashworth A, Gentry-Maharaj A, Jones M, Ramus SJ, Orr N, Menon U, Pearce CL, Brüning T, Pike MC, Ko YD, Lissowska J, Figueroa J, Kupryjanczyk J, Chanock SJ, Dansonka-Mieszkowska A, Jukkola-Vuorinen A, Rzepecka IK, Pylkäs K, Bidzinski M, Kauppila S, Hollestelle A, Seynaeve C, Tollenaar RA, Durda K, Jaworska K, Hartikainen JM, Kosma VM, Kataja V, Antonenkova NN, Long J, Shrubsole M, Deming-Halverson S, Lophatananon A, Siriwanarangsan P, Stewart-Brown S, Ditsch N, Lichtner P, Schmutzler RK, Ito H, Iwata H, Tajima K, Tseng CC, Stram DO, van den Berg D, Yip CH, Ikram MK, Teh YC, Cai H, Lu W, Signorello LB, Cai Q, Noh DY, Yoo KY, Miao H, Iau PT, Teo YY, McKay J, Shapiro C, Ademuyiwa F, Fountzilas G, Hsiung CN, Yu JC, Hou MF, Healey CS, Luccarini C, Peock S, Stoppa-Lyonnet D, Peterlongo P, Rebbeck TR, Piedmonte M, Singer CF, Friedman E, Thomassen M, Offit K, Hansen TV, Neuhausen SL, Szabo CI, Blanco I, Garber J, Narod SA, Weitzel JN, Montagna M, Olah E, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Imyanitov EN, Tihomirova L, Arun BK, Campbell I, Mensenkamp AR, van Asperen CJ, van Roozendaal KE, Meijers-Heijboer H, Collée JM, Oosterwijk JC, Hooning MJ, Rookus MA, van der Luijt RB, Os TA, Evans DG, Frost D, Fineberg E, Barwell J, Walker L, Kennedy MJ, Platte R, Davidson R, Ellis SD, Cole T, Bressac-de Paillerets B, Buecher B, Damiola F, Faivre L, Frenay M, Sinilnikova OM, Caron O, Giraud S, Mazoyer S, Bonadona V, Caux-Moncoutier V, Toloczko-Grabarek A, Gronwald J, Byrski T, Spurdle AB, Bonanni B, Zaffaroni D, Giannini G, Bernard L, Dolcetti R, Manoukian S, Arnold N, Engel C, Deissler H, Rhiem K, Niederacher D, Plendl H, Sutter C, Wappenschmidt B, Borg A, Melin B, Rantala J, Soller M, Nathanson KL, Domchek SM, Rodriguez GC, Salani R, Kaulich DG, Tea MK, Paluch SS, Laitman Y, Skytte AB, Kruse TA, Jensen UB, Robson M, Gerdes AM, Ejlertsen B, Foretova L, Savage SA, Lester J, Soucy P, Kuchenbaecker KB, Olswold C, Cunningham JM, Slager S, Pankratz VS, Dicks E, Lakhani SR, Couch FJ, Hall P, Monteiro AN, Gayther SA, Pharoah PD, Reddel RR, Goode EL, Greene MH, Easton DF, Berchuck A, Antoniou AC, Chenevix-Trench G, Dunning AM. Nat Genet. 2013 Apr;45(4):371-84, 384e1-2. doi: 10.1038/ng.2566. PMID: 23535731.
  5. Alternative lengthening of telomeres: remodeling the telomere architecture. Conomos D, Pickett HA, Reddel RR. Front Oncol. 2013 Feb 20;3:27. doi: 10.3389/fonc.2013.00027. eCollection 2013. PMID: 23429284.
  6. Alternative lengthening of telomeres in normal mammalian somatic cells. Neumann AA, Watson CM, Noble JR, Pickett HA, Tam PP, Reddel RR. Genes Dev. 2013 Jan 1;27(1):18-23. doi: 10.1101/gad.205062.112. PMID: 23307865.
  7. STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Peña C, Céspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, Sandström P, Olsson E, Veerla S, Gallardo A, Sjöblom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A. Cancer Res. 2013 Feb 15;73(4):1287-97. doi: 10.1158/0008-5472.CAN-12-1875. Epub 2012 Dec 14. PMID: 23243022.
  8. Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA. J Cell Biol. 2012 Dec 10;199(6):893-906. doi: 10.1083/jcb.201207189. PMID: 23229897.
  9. Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres. Bower K, Napier CE, Cole SL, Dagg RA, Lau LM, Duncan EL, Moy EL, Reddel RR. PLoS One. 2012;7(11):e50062. doi: 10.1371/journal.pone.0050062. Epub 2012 Nov 20. PMID: 23185534.
  10. Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. Bender HS, Murchison EP, Pickett HA, Deakin JE, Strong MA, Conlan C, McMillan DA, Neumann AA, Greider CW, Hannon GJ, Reddel RR, Graves JA. PLoS One. 2012;7(9):e46195. doi: 10.1371/journal.pone.0046195. Epub 2012 Sep 25. PMID: 23049977.
  11. Enhanced isolation of fibroblasts from human skin explants. Huschtscha LI, Napier CE, Noble JR, Bower K, Au AY, Campbell HG, Braithwaite AW, Reddel RR. Biotechniques. 2012 Oct;53(4):239-44. doi: 10.2144/0000113939. PMID: 23046507.
  12. Detection of alternative lengthening of telomeres by telomere quantitative PCR. Lau LM, Dagg RA, Henson JD, Au AY, Royds JA, Reddel RR. Nucleic Acids Res. 2013 Jan;41(2):e34. doi: 10.1093/nar/gks781. Epub 2012 Aug 25. PMID: 22923525.


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