Healthier kids, brighter futures

Publications

Cell Biology Unit

Selected Key Publications:

  1. Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding. Tomlinson GG, Moye AL, Holien JK, Parker MW, Cohen SB, Bryan TM. Biochem. 2014, Nov 3. doi: 10.1042/BJ20140922. PMID: 25365545
  2. Telomere elongation in immortal human cells without detectable telomerase activity. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. EMBO J. 1995, 14: 4240-4248. PMID: 7556065.
  3. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Bryan TM, Sperger JM, Chapman KB, Cech TR. Proc Natl Acad Sci U S A. 1998, 95(15):8479-84. PMID:9671703.
  4. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Bryan TM, Goodrich KJ and Cech TR. Mol. Cell 2000, 6: 493-499. PMID: 10983995.
  5. Extension of G-quadruplex DNA by ciliate telomerase. Oganesian L, Moon IK, Bryan TM and Jarstfer MB. EMBO J. 2006, 25, 1148-59. PMID: 16511573.
  6. Direct involvement of the TEN domain at the active site of human telomerase. Jurczyluk, J, Nouwens, AS, Holien, JK, Adams, TE, Lovrecz, GO, Parker, MW, Cohen, SB, and Bryan, TM. Nucleic Acids Res 2011, 39:1774-88. PMID: 21051362.
  7. Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Stern JL, Zyner KG, Pickett HA, Cohen SB, Bryan TM. Mol Cell Biol. 2012 Jul;32(13):2384- 95. Epub 2012 Apr 30. PMID: 22547674.
 
Access the recommendation on F1000Prime

Recent Publications:

  1. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Guo, Y., Kartawinata, M., Li, J., Pickett, H. A., Teo, J., Kilo, T., Barbaro, P. M., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R. R., Christodoulou, J., Xu, X., Hakonarson, H., and Bryan, T. M., 2014. Blood 2014-08-596445. PMID: 25205116.
  2. Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA. J Cell Biol. 2012 Dec 10;199(6):893-906. PMID: 23229897.
  3. Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Stern JL, Zyner KG, Pickett HA, Cohen SB, Bryan TM. Mol Cell Biol. 2012 Jul;32(13):2384- 95. Epub 2012 Apr 30. PMID 22547674.
  4. Direct involvement of the TEN domain at the active site of human telomerase. Jurczyluk, J, Nouwens, AS, Holien, JK, Adams, TE, Lovrecz, GO, Parker, MW, Cohen, SB, and Bryan, TM. Nucleic Acids Res. 2011, 39:1774-88. PMID: 21051362.
  5. Amplification of hTERT in human mammary epithelial cells with limiting hTR expression levels. Cao Y, Huschtscha LI, Nouwens AS, Pickett HA, Neumann AA, Chang AC-M, Toouli CD, Bryan TM, Reddel RR. Cancer Res. 2008, 68: 3115-23. PMID: 18451136.
  6. Multiple DNA binding sites in Tetrahymena telomerase. Finger SN, Bryan TM. Nucleic Acids Res. 2008, 36: 1260-1272. PMID: 18174223.
  7. Telomerase recognizes G-quadruplex and linear DNA as distinct substrates. Oganesian L, Graham ME, Robinson PJ, Bryan TM. Biochemistry 2007, 46: 11279-90. PMID: 17877374.
  8. Structure of stem-loop IV of Tetrahymena telomerase RNA. Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G. EMBO J. 2006, 25: 3156-66. PMID: 16778765.
  9. Extension of G-quadruplex DNA by ciliate telomerase. Oganesian L, Moon IK, Bryan TM, Jarstfer MB. EMBO J. 2006, 25: 1148-59. PMID: 16511573.

Selected Review Articles:

  1. G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Bryan TM and Baumann P. Mol. Biotechnol. 2011, Epub Mar 17. PMID: 21416200.
  2. Telomerase recruitment to telomeres. Stern JL and Bryan TM. Cytogenet. Genome Res. 2008, 122: 243-54. PMID: 19188693.
  3. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cao Y, Bryan TM and Reddel RR. Cancer Sci. 2008, 99: 1092-1099. PMID: 18482052.
  4. Physiological relevance of telomeric G-quadruplex formation: a potential drug target. Oganesian L and Bryan TM. Bioessays 2007, 29: 155-165. PMID: 17226803.
  5. Interrogation of G-quadruplex-protein interactions. Bryan TM, Jarstfer MB. Methods. 2007, Dec;43(4):332-9. Review. PMID:17967703.
  6. Telomerase and the maintenance of chromosome ends. Bryan TM, Cech TR. Curr Opin Cell Biol. 1999, 11(3):318-24. Review. PMID:10395557.

Book Chapters:

  1. Bryan, T.M. Telomeres and the end replication problem.  In: Molecular Themes in Eukaryotic DNA Replication, ed. Lynne Cox, Royal Society of Chemistry, Cambridge, 2009.
  2. Bryan, T.M. and Baumann, P. G-quadruplexes: from guanine gels to chemotherapeutics.  In: G-quartets: Reviews and Protocols, Methods in Molecular Biology, Springer, 2009.
  3. Tomlinson, C.G., Cohen, S.B. and Bryan, T.M. Inhibition of telomerase: promise, progress and potential pitfalls. In: Cancer Drug Design and Discovery, 2nd Edition, ed. Stephen Neidle, Elsevier, 2013.