Basic research: molecular mechanisms of mitosis
Despite the identification of many mitotic proteins, the molecular mechanisms driving mitotic progression and how these proteins cooperatively function to complete mitosis in mammalian cells is not fully understood. Cell division errors increase the potential of a cell becoming cancerous. Thus, understanding this basic biological process underpins our understanding of cancer biology mechanisms, which can lead to the identification of targets for therapeutic anti-cancer drug design.
Translational biology: drug discovery of new anti-mitotic compounds for cancer treatment
We have discovered that a subset of endocytic proteins are required for mitotic progression. Two of these have been identified as anti-cancer drug targets, as their specific inhibitors exhibit cytotoxic and cell growth inhibitor properties. This strong foundation will be developed into the future as we expand our drug development program.