Healthier kids, brighter futures

Research

Publications

Cell Cycle Unit

  1. Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.Tremblay C, Brown F, Collett M, Saw J, Chiu S, Sonderegger S, Lucas S, Alserihi R, Chau N, Toribio M, McCormack M, Chircop M, Robinson PJ, Jane S, Curtis D. (2016).  Leukemia. Accepted 14th April 2016. Manuscript ID: 15-LEU-1633R
  2. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ. Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9. PMID: 24025110.
  3. Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation. Ma MP, Robinson PJ, Chircop M. PLoS One. 2013 Jul 5;8(7):e68387. doi: 10.1371/journal.pone.0068387. Print 2013. PMID: 23861900.
  4. CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci. Boutros R, Mondesert O, Lorenzo C, Astuti P, McArthur G, Chircop M, Ducommun B, Gabrielli B. PLoS One. 2013 Jul 1;8(7):e67822. doi: 10.1371/journal.pone.0067822. Print 2013. PMID: 23840880.
  5. Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors. McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ. ACS Chem Biol. 2013 May 30. [Epub ahead of print] PMID: 23642287.
  6. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M. Mol Cancer. 2013 Jan 17;12:4. doi: 10.1186/1476-4598-12-4. PMID: 23327284.
  7. Development of second-generation indole-based dynamin GTPase inhibitors. Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A. J Med Chem. 2013 Jan 10;56(1):46-59. doi: 10.1021/jm300844m. Epub 2012 Dec 18. PMID: 23167654.
  8. Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion. Smith CM, Chircop M. Traffic 2012 Dec;13(12):1628-41. Epub 2012 Sep 7. PMID 22901037.
  9. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. Ma MP, Chircop M. J Cell Sci. 2012 Sep 15;125(Pt 18):4372-82. Epub 2012 Jun 20. PMID 22718350.
  10. Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. Chircop M, Sarcevic B, Larsen MR, Malladi CS, Chau N, Zavortink M, Smith CM, Quan A, Anggono V, Hains PG, Graham ME, Robinson PJ. Biochem Biophys Acta 2011 1813(10):1689-99. Epub 2010 Dec 29. PMID: 21195118.
  11. Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Joshi S, Braithwaite AW, Robinson PJ, Chircop M. Mol Cancer 2011 10(1):78. PMID: 21708043.
  12. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O’Brien TJ, McCluskey A, Robinson PJ. Mol Cancer Ther 2011 Epub Jul 12. PMID: 21750222.
  13. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, Macgregor KA, Tomlin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V (2011). Cell, 146(3):471-84. PMID: 21816279.
  14. CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity. Boutros R, Lorenzo C, Mondesert O, Jauneau A, Oakes V, Dozier C, Gabrielli B, Ducommun B. Biol Cell 2011 103: 55-68. PMID: 21091437.