Healthier kids, brighter futures

Publications

Cell Signalling Unit


Recent Publications

  1. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ. Traffic. 2013, Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9. PMID: 24025110
  2. PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Anggono V, Koç-Schmitz Y, Widagdo J, Kormann J, Quan A, Chen CM, Robinson PJ, Choi SY, Linden DJ, Plomann M, Huganir RL. Proc Natl Acad Sci USA. 2013 Aug 20;110(34):13976-81. doi: 10.1073/pnas.1312467110. Epub 2013 Aug 5. PMID: 23918399
  3. Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation. Ma MP, Robinson PJ, Chircop M. PLoS One. 2013 Jul 5;8(7):e68387. doi: 10.1371/journal.pone.0068387. Print 2013. PMID: 23861900
  4. Syndapin - a membrane remodelling and endocytic F-BAR protein. Quan A, Robinson PJ. FEBS J. 2013 Nov;280(21):5198-212. doi: 10.1111/febs.12343. Epub 2013 Jul 5. PMID: 23668323
  5. Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors. McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ. ACS Chem Biol. 2013 May 30. [Epub ahead of print] PMID: 23642287
  6. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M. Mol Cancer. 2013 Jan 17;12:4. doi: 10.1186/1476-4598-12-4. PMID: 23327284
  7. Development of second-generation indole-based dynamin GTPase inhibitors. Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A. J Med Chem. 2013 Jan 10;56(1):46-59. doi: 10.1021/jm300844m. Epub 2012 Dec 18. PMID: 23167654
  8. Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Quan A, Xue J, Wielens J, Smillie KJ, Anggono V, Parker MW, Cousin MA, Graham ME, Robinson PJ. Proc Natl Acad Sci USA 2012 Mar 6;109(10):3760-5. Epub 2012 Feb 21. PMID 22355135
  9. Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked β-N-acetylglucosaminyl-6-phosphate modification. Graham ME, Stone RS, Robinson PJ, Payne RJ. Org Biomol Chem. 2012 Apr 7;10(13):2545-51. Epub 2012 Feb 24. PMID 22361808
  10. Identification and characterisation of the RalA-ERp57 interaction: evidence for GDI activity of ERp57. Brymora A, Duggin IG, Berven LA, van Dam EM, Roufogalis BD, Robinson PJ. PLoS One 2012;7(11):e50879. Epub 2012 Nov 30. PMID 23226417 

     

Key Publications

  1. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Liu J-P, Sim ATR and Robinson PJ. Science 1994, 265: 970-973. PMID: 8052858
  2. Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals. Cousin MA and Robinson PJ. J Neurochem. 2000, 75: 1645-1653. PMID: 10987846
  3. The brain exocyst complex interacts with RalA in a GTP-dependent manner: Identification of a novel mammalian Sec3 gene and a second Sec15 gene. Brymora A, Valova VA, Larsen MR, Roufogalis BD and Robinson PJ. J Biol. Chem. 2001, 276: 29792-29797. PMID: 11406615
  4. Cdk5 is essential for synaptic vesicle endocytosis. Tan TC, Valova VA, Malladi CS, Graham ME, Berven LA, Jupp OJ, Hansra G, McClure SJ, Sarcevic B, Boadle RA, Larsen MR, Cousin MA and Robinson PJ. Nat. Cell Biol. 2003, 5: 701-710. PMID: 12855954

Review Articles

  1. Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Harper CB, Popoff MR, McCluskey A, Robinson PJ, Meunier FA. Trends Cell Biol. 2013 Feb;23(2):90-101. doi: 10.1016/j.tcb.2012.10.007. Epub 2012 Nov 17. Review. PMID: 23164733
  2. Mechanisms of calcineurin inhibitor-induced neurotoxicity. Tan TC and Robinson PJ. Transplant Rev. (Orlando) 2006, 20: 49-60.
  3. Ral: Mediator of membrane trafficking. van Dam EM and Robinson PJ. Int. J Biochem. Cell Biol. 2006, 38: 1841-7. PMID: 16781882
  4. Protein-protein interactions identified by pull-down experiments and mass spectrometry. Brymora A, Valova VA, Robinson PJ. Curr. Protoc. Cell Biol. 2004, Chapter 17: Unit 17.5. PMID: 18228443
  5. The dephosphins: Dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Cousin MA and Robinson PJ. Trends Neurosci. 2001, 24: 659-665. PMID: 11672811
  6. Mechanisms of synaptic vesicle recycling illuminated by fluorescent dyes. Cousin MA and Robinson PJ. J Neurochem. 1999, 73: 2227-2239. PMID: 10582580