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Publications

Telomere Length Regulation Group

 

Recent Publications

Anagha Killedar, Michael D. Stutz, Alexander P. Sobinoff, Christopher G. Tomlinson, Tracy M. Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R. Reddel, Hilda A. Pickett, 2015. A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. 2015DOI: 10.1371/journal.pgen.1005286

Guo, Y., Kartawinata, M., Li, J., Pickett, H. A., Teo, J., Kilo, T., Barbaro, P. M., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R. R., Christodoulou, J., Xu, X., Hakonarson, H., Bryan, T. M., 2014. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood 2014-08-596445. PMID: 25205116.
 
Conomos, D., Reddel, R. R., Pickett, H. A., 2014. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat. Struct. Mol. Biol. 21, 760-770. PMID:25150861.

Bull, C. F., Mayrhofer, G., O’Callaghan, N. J., Au, A. Y., Pickett, H. A., Kah Mun Low, G., Zeegers, D., Hande, M. P., Fenech, M. F., 2013. Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells. Cancer Prev. Res. 7, 128-138. PMID: 24253316.
 
Lee, M., Hills, M., Conomos, D., Stutz, M. D., Dagg, R. A., Lau, L. M. S., Reddel, R. R., Pickett, H. A., 2013. Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res. Accepted 22/10/13. PMID: 24225324.
 
Kojima, Y., Kaufman-Francis, K., Studdert, J. B., Steiner, K. A., Power, M. D., Loebel, D. A. F., Jones, V., Hor, A., de Alencastro, G., Logan, G., Teber, E. T., Tam, O. H., Stutz, M. D., Alexander, I. E., Pickett, H. A., Tam, P. P. L., 2013. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. Cell Stem Cell 14, 107-120. PMID: 24139757.
 
Bojesen, S. E., Pooley, K. A., Johnatty, S. E., Beesley, J., Michailidou, K., Tyrer, J. P., Edwards, S. L., Pickett, H. A., Shen, H. C., Smart, C. E., Hillman, K. M., Mai, P. L., Lawrenson, K., Stutz, M. D., Yu, L., Karevan, R., Woods, N., Johnston, R. L., French, J. D., Chen, X., Weischer, M., Nielsen, S. F., Maranian, M.J., Ghoussaini, M., Ahmed, S., et al., 2013. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat. Genet. 45, 371-384. PMID: 23535731.
 
Conomos, D., Pickett, H. A., Reddel, R. R., 2013. Alternative lengthening of telomeres: remodeling the telomere architecture. Front. Oncol. 3:27. doi: 10.3389/fonc.2013.00027. PMID: 23429284.
 
Neumann, A. A., Watson, C. M., Noble, J. R., Pickett, H. A., Tam, P. T., Reddel, R. R., 2013. Alternative lengthening of telomeres in normal mammalian somatic cells. Genes Dev. 27, 18-23. PMID: 23307865.
 
Conomos, D., Stutz, M. D., Hills, M., Neumann, A. A., Bryan, T. M., Reddel, R. R., Pickett, H. A., 2012. Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J. Cell Biol. 199, 893-906. PMID: 23229897.
 
Bender, H. S., Murchison, E. P., Pickett, H. A., Deakin, J. E., Strong, M. A., Conlan, C., McMillan, D. A., Neumann, A. A., Greider, C. W., Hannon, G. J., Reddel, R. R., Graves, J. A., 2012. Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLOS One 7(9):e46195. PMID: 23049977.
 
Uringa, E. J., Lisaingo, K., Pickett, H. A., Brind’Amour, J., Rohde, J. H., Zelensky, A., Essers, J., Lansdorp, P. M., 2012. RTEL1 contributes to DNA replication, repair and telomere maintenance. Mol. Biol. Cell. 23, 2782-2792. PMID: 22593209.
 
Stern, J. L., Zyner, K. G., Pickett, H. A., Cohen, S. B., Bryan, T. M., 2012. Two independent mechanisms control telomerase recruitment to the telomere. Mol. Cell Biol. 32, 2384-2395. PMID: 22547674.
 
Pickett, H. A., Reddel, R. R., 2012. The role of telomere trimming in normal telomere length dynamics. Cell Cycle 11, 1309-1315. PMID: 22421147.
 
 

Key Publications

Conomos, D., Reddel, R. R., Pickett, H. A., 2014. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat. Struct. Mol. Biol. 21, 760-770. PMID: 25150861.
 
Lee, M., Hills, M., Conomos, D., Stutz, M. D., Dagg, R. A., Lau, L. M. S., Reddel, R. R., Pickett, H. A., 2014. Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res. 42, 1733-1746. PMID: 24225324
 
Conomos, D., Pickett, H. A., Reddel, R. R., 2013. Alternative lengthening of telomeres: remodeling the telomere architecture. Front. Oncol. 3:27. doi: 10.3389/fonc.2013.00027. PMID: 23429284.
 
Conomos, D., Stutz, M. D., Hills, M., Neumann, A. A., Bryan, T. M., Reddel, R. R., Pickett, H. A., 2012. Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J. Cell Biol. 199, 893-906. PMID: 23229897.
 
Pickett, H. A., Henson, J. D., Au, A. Y. M., Neumann, A. A., Reddel, R. R., 2011. Normal mammalian cells negatively regulate telomere length by telomere trimming. Hum. Mol. Gen. 20, 4684-4692. PMID: 21903669.
 
Pickett, H. A., Cesare, A. J., Johnston, R. L., Neumann, A. A., Reddel, R. R., 2009. Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J. 28, 799-809. PMID: 19214183.
 
Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R., Royle, N. J., 2002. Molecular characterisation of inter-telomere and intra-telomere mutations in human ALT cells. Nat. Genet. 30, 301-305. PMID: 11919561